Association of gene polymorphisms in the anti-Müllerian hormone signalling pathway with ovarian function: a systematic review and meta-analysis

Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): Ran Cheng, Wei Xiong, Xiaoyan Luo, Yaxian Ma, Ying Nie, Xiaoyong Qiao, Hui Chen, Ying Hu, Liangzhi XuAbstractThis systematic review evaluated whether single nucleotide polymorphisms of AMH and AMHRII genes are associated with ovarian function. A literature search of PubMed and Embase was complemented by hand searches in the reference lists. Eight studies involving 3155 participants were included in a meta-analysis and 10 studies included for description. For AMH c.146T>G polymorphism, no significant difference in serum anti-Müllerian hormone (AMH) levels was found between participants with different genotypes (weighted mean difference [WMD] 0.42, 95% confidence interval [CI] −0.16 to 0.99). Subgroup analyses showed similar results for the European region and in healthy and infertile populations. Regarding AMHRII −482 A>G, there was no significant difference in serum AMH levels between participants with A/A genotype and G/A or G/G genotype carriers (WMD –0.04, 95% CI −0.31 to 0.23). In subgroup analysis, an interesting trend was confirmed in healthy women and polycystic ovary syndrome (PCOS) patients (WMD –0.36, 95% CI −0.63 to –0.09, P = 0.009; WMD 0.46, 95% CI 0.15 to 0.77, P = 0.004). The review suggests that AMH c.146T>G is not associated with AMH levels, while AMHRII −482 A>G may be related to AMH levels in PCOS and healthy subgroups. However, the imp...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research