Mechanisms of hypoxia signalling: new implications for nephrology

Nature Reviews Nephrology, Published online: 05 September 2019; doi:10.1038/s41581-019-0182-zTherapeutic modulation of hypoxia-inducible factors, which transduce adaptive transcriptional responses to hypoxia, is an emerging theme in kidney disease. This Review summarizes the hypoxia signalling mechanisms underpinning these novel treatments and highlights key remaining questions relevant to their clinical use.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research