Radiation ‐induced oesophagitis in breast cancer: Factors influencing onset and severity for patients receiving supraclavicular nodal irradiation

AbstractAimThe aim of this study was to determine dosimetric factors, such as mean dose and oesophageal length, which may influence the incidence and severity of oesophagitis in breast cancer patients receiving radiotherapy to the supraclavicular nodes.MethodsThis was a single ‐arm prospective observational study. Toxicity grading was undertaken twice weekly to determine the onset of grade 2 oesophagitis in consecutive patients prescribed IMRT to the breast or chest wall and supraclavicular fossa (SCF) nodes. Recorded variables included mean and maximum doses to the oes ophagus, oesophageal length and pharynx length within the treatment area. Multivariate logistic regression and Fishers’ exact test were used with a 0.05 significance level to compare the onset of grade 2 oesophagitis with these variables.ResultsA total of 77 patients were included in the study. Twenty ‐four (31%) patients reported grade 2 oesophagitis. There was a higher incidence of grade 2 oesophagitis in patients receiving a mean oesophageal dose of ≥31 Gy compared to those receiving
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Radiation Oncology —Original Article Source Type: research

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Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The aim of this study was to identify and compare cancer sites whose incidence is influenced by social deprivation. The study population comprised 189 144 cases of cancer diagnosed between 2006 and 2009, recorded in member registries of the French Network of Cancer Registries. Social environment was assessed at an aggregate level using the European Deprivation Index. The association between incidence and socioeconomic status was assessed by a geographical Bayesian Poisson model enabling a reduction of the overall variability and smoothing of the relative risks by sharing information provided by multiple geographic u...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Epidemiology Source Type: research
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
ConclusionsEducation is inversely associated with total cancer mortality, and the association was stronger in men. Different patterns and trends in tobacco smoking in men and women account for at least most of the gender differences.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
A new study suggests that alcohol is a direct cause of cancer in several areas of the body. The study, published Thursday in the scientific journal Addiction, consists of a major review of 10 years’ worth of studies from several organizations, including the World Cancer Research Fund, the American Institute for Cancer Research and the International Agency for Research on Cancer. And its conclusions are dire.  Nearly 6 percent of cancer deaths worldwide can be linked to alcohol, including in people who drink light to moderate amounts of alcohol, the study concludes. “From a public health perspective, a...
Source: Science - The Huffington Post - Category: Science Source Type: news
An opinion piece published in the scientific journal Addiction in July gathers evidence to argue that alcohol is a direct cause of cancer in several areas of the body. The article reviews 10 years’ worth of studies from several organizations, including the World Cancer Research Fund, the American Institute for Cancer Research and the International Agency for Research on Cancer. And its conclusions are dire.  Nearly 6 percent of cancer deaths worldwide can be linked to alcohol, including in people who drink light to moderate amounts of alcohol, according to author Jennie Connor, a profess...
Source: Science - The Huffington Post - Category: Science Source Type: news
Conclusion This narrative review aimed to summarise data from published biological and epidemiological research to discuss the strength of evidence that alcohol causes cancer. The author gives their main finding as a link between alcohol consumption and cancer at seven sites, and also that the highest risks seem to be associated with heavier drinking. However, they state there's no "safe" drinking threshold and that low to moderate consumption still contributes to a significant number of cancer cases. The biggest limitation of this review is that it doesn't appear to be systematic. The author provided no method...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news
CONCLUSION: It is concluded that the lungs and contralateral breast showed high LAR estimates. PMID: 27379458 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
(NaturalNews) In 1987, a working group of the International Agency for Research on Cancer (IARC) – an agency of the World Health Organization (WHO) – listed cancers of the oral cavity, pharynx, larynx, esophagus and liver as "causally related to the consumption of alcoholic...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion Our findings confirm dose-dependent associations between long-term alcohol intake and breast, UADT and colorectal cancer.
Source: Alcohol and Alcoholism - Category: Addiction Authors: Tags: EPIDEMIOLOGY Source Type: research
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