Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.

Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.
Chemistry. 2019 Sep 03;:
Authors: Wu R, Chen H, Chang N, Xu Y, Jiao J, Zhang H
Abstract
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease and cancer. This comprehensive account summarizes the recent progress (2014-present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most-studied analog to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.
PMID: 31479550 [PubMed - as supplied by publisher]

Source: Chemistry - September 2, 2019 Category: Chemistry Authors: Wu R, Chen H, Chang N, Xu Y, Jiao J, Zhang H Tags: Chemistry Source Type: research