Recent advances in application of azobenzenes grafted on Mesoporous Silica Nanoparticles in controlled Drug Delivery Systems using light as external stimulus.

Recent advances in application of azobenzenes grafted on Mesoporous Silica Nanoparticles in controlled Drug Delivery Systems using light as external stimulus. Mini Rev Med Chem. 2019 Sep 04;: Authors: Ramírez-Rave S, Bernad-Bernad MJ, Gracia-Mora J, Yatsimirsky AK Abstract Hybrid materials based in mesoporous silica nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of drug delivery systems (DDS) is not an exception. MSN present a desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is using of external stimuli for drug release. In this context light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last 3 years with emphasize on usually overlooked underlying chemistry, photophysical properties and supramolecular complexation of azobenzenes. PMID: 31483228 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research