Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs

In conclusion, the effects of AADs are highly complex and strongly dependent on the experimental or clinical conditions. MANTA is a powerful and freely available tool reproducing a wide range of AAD characteristics that enables analyses of the underlying ionic mechanisms. Use of MANTA is expected to improve our understanding of AAD effects on cellular electrophysiology under a wide range of conditions, which may provide clinically-relevant information on the safety and efficacy of AAD treatment.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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ConclusionThe overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
CONCLUSION: The overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes. PMID: 31521944 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
DiscussionRemote monitoring may improve clinical outcome if it uncovers conditions with low symptom burden which cause or indicate an increased risk. A simple and easily implementable response to the information is important. Cardiac arrhythmias frequently start as asymptomatic, shorter lasting, and nightly events. The BIO-GUARD-MI trial represents the first attempt to simplify the response to the rather complex nature of heart arrhythmias.Trial registrationClinical Trials,NCT02341534. Registered on 19 January 2015.
Source: Trials - Category: Research Source Type: clinical trials
Hypertension is the most common cardiovascular risk factor and underlies heart failure, coronary artery disease, stroke, and chronic kidney disease. Hypertensive heart disease can manifest as cardiac arrhythmias. Supraventricular and ventricular arrhythmias may occur in the hypertensive patients. Atrial fibrillation and hypertension contribute to an increased risk of stroke. Some antihypertensive drugs predispose to electrolyte abnormalities, which may result in atrial and ventricular arrhythmias. A multipronged strategy involving appropriate screening, aggressive lifestyle modifications, and optimal pharmacotherapy can re...
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
Cardiac arrhythmias are common after cardiac surgery and have profound sequelae. Bradycardias are typically transient and have reversible causes; however, persistent atrioventricular block is an indicator for permanent pacemaker implantation after valvular surgery. Transcatheter aortic valve surgery is associated with even higher rates of permanent pacemaker implantation. Atrial fibrillation, the most common postoperative arrhythmia, is associated with ischemic stroke, myocardial infarction, congestive heart failure, and short-term mortality. Ventricular arrhythmias have extremely high in-hospital mortality, as well as lon...
Source: Critical Care Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
Cardiac arrhythmias are common after cardiac surgery and have profound sequelae. Bradycardias are typically transient and have reversible causes; however, persistent atrioventricular block is an indicator for permanent pacemaker implantation after valvular surgery. Transcatheter aortic valve surgery is associated with even higher rates of permanent pacemaker implantation. Atrial fibrillation, the most common postoperative arrhythmia, is associated with ischemic stroke, myocardial infarction, congestive heart failure, and short-term mortality. Ventricular arrhythmias have extremely high in-hospital mortality, as well as lon...
Source: Critical Care Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
BIOTRONIK is releasing a new version of its popular BIOMONITOR injectable cardiac monitor. The BIOMONITOR III is less than half the size of the BIOMONITOR 2, while offering much clearer signal quality. It is designed to be injected under the s...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Cardiology Source Type: blogs
ATRIAL FIBRILLATION (AF), A COMMON CARDIAC ARRHYTHMIA AND A LEADING CAUSE OF STROKE AND HEART FAILURE, CAN DECREASE EXERCISE TOLERANCE AND QUALITY OF LIFE. COMPREHENSIVE, INDIVIDUALIZED EXERCISE PROGRAMS ARE SAFE AND CAN REDUCE CARDIOVASCULAR DISEASE RISKS AND ENHANCE PHYSICAL FITNESS AND QUALITY OF LIFE IN MEDICALLY CLEARED CLIENTS WITH AF.
Source: Strength and Conditioning Journal - Category: Sports Medicine Tags: Columns: Special Populations Source Type: research
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with increasing incidence worldwide. Much focus has been directed towards AF prevention, given the morbidity and mortality from stroke, heart failure, and dementia. There are a number of common conditions associated with the onset of AF including, but not limited to, increased alcohol consumption, body weight, exercise, and stress. To reduce the incidence of AF, public health campaigns and targeted patient interventions may be warranted to promote balanced alcohol intake, appropriate exercise, and stress management to prevent AF and ...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
BioSig Technologies has developed the PURE EP electrophysiology information system, a product that aims to provide better tools for doctors who are treating potentially deadly arrhythmias. The computerized system is used to process electrophysiologic...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Exclusive Source Type: blogs
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