Phytochemicals as potential IKK- β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones

In this study, the interactions between different classes of inhibitors and IKK-β were investigated, through the application of SystemsDock. Molecular docking results showed that Diosgenin and Ginsenoside Re were the top docking score compounds. Diosgenin and Ginsenoside Re are the most promising IKK-β inhibitors in terpenoids, alkaloids, and quinones. Diosgenin and Ginsenoside Re could be helpful to find the lead compou nds on designing and developing novel cardioprotective agents.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research