2019 HRS/EHRA/APHRS/LAHRS focused update to 2015 expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

AbstractThe2015 HRS/EHRA/APHRS/SOLAECE Expert Consensus Statement on Optimal Implantable Cardioverter-De fibrillator Programming and Testing provided guidance on bradycardia programming, tachycardia detection, tachycardia therapy, and defibrillation testing for implantable cardioverter-de fibrillator (ICD) patient treatment. The 32 recommendations represented the consensus opinion of the writing group, graded by Class of Recommendation and Level of Evidence. In addition, Appendix B provided manufacturer-specific translations of these recommendations into clinical practice consistent with the recommendations within the parent document. In some instances, programming guided by quality evidence gained from studies performed in devices from some manufacturers was translated such that this programming was approximated in another manufacturer’s ICD programming settings. The author s found that the data, although not formally tested, were strong, consistent, and generalizable beyond the specific manufacturer and model of ICD. As expected, because these recommendations represented strategic choices to balance risks, there have been reports in which adverse outcomes were documen ted with ICDs programmed to Appendix B recommendations. The recommendations have been reviewed and updated to minimize such adverse events. Notably, patients who do not receive unnecessary ICD therapy are not aware of being spared potential harm, whereas patients in whom their ICD failed to treat li fe...
Source: Europace - Category: Cardiology Source Type: research

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This study provides a potential therapeutic target for VA in HF.
Source: Life Sciences - Category: Biology Source Type: research
Authors: Petropoulos AC, Moschovi M Abstract Late cardiotoxicity following treatment of malignancy diseases has been long established. Cancer therapeutics-related cardiac dysfunction (CTRCD), acute arrhythmias, pericardial disease, valvopathies and early atherosclerotic Cardiovascular Disease (CVD), are the clinical presentations of cardiotoxicity. Although these clinical modalities can affect adults treated for malignancies, they are more common to present in the pediatric survivors as improvement of prognosis, nowadays exists. Studies have shown that CVD can present earlier than thirty years, post treatment. If a...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
In this study, we describe the morphometry of the sinus and atrioventricular nodes of 10 adult humans and 10 pig hearts. A computerized morphometric study has been carried out, where we determined the number of cells that compose the nodes as well as different parameters related to their shape and size.The sinus node in human and pig is a compact structure, whose shape is oblong. Their cells (nodal and transitional cells) are pale and located in the center and the periphery, respectively. The atrioventricular node has also a shape oblong. P cells are pale in both species, but in humans, they are smaller than cardiomyocytes...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Conclusions:This pooled analysis of AE data from one Phase 2 and three Phase 3 completed eliglustat trials demonstrates long-term safety and tolerability of eliglustat in the treatment of adults with GD1.DisclosuresPeterschmitt: Sanofi Genzyme: Employment. Freisens: Sanofi Genzyme: Employment. Hou: Sanofi Genzyme: Employment. Underhill: Sanofi Genzyme: Employment. Foster: Sanofi Genzyme: Employment. Gaemers: Sanofi Genzyme: Employment.
Source: Blood - Category: Hematology Authors: Tags: 201. Granulocytes, Monocytes, and Macrophages: Poster III Source Type: research
Researchers at Children’s National Health System, working with engineers from Medtronic, have created a pacemaker appropriately tiny enough to implant into infants. Measuring only one cubic centimeter, about the size of a large pill, it al...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Cardiology Pediatrics Source Type: blogs
We present here a 42-year-old man with an inverted Takotsubo variant with pulmonary edema and transient accelerated idioventricular rhythm. He was initially admitted in the Emergency Department for acute and non-complicated appendicitis. Coronary angiogram showed normal coronary arteries and left ventriculography revealed a reverse variant of TTC. The patient had completely recovered. Myocarditis was ruled out by cardiac magnetic resonance imaging.
Source: Journal of Emergencies, Trauma and Shock - Category: Emergency Medicine Authors: Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 211 – the spooky halloween edition. Question 1 Can you be scared to death? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1389326136'));expand(document.getElementById('ddetlink1389326136')) Yes, there are multiple media r...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five appendix bram stokes dracula Houdini huffing sudden sniffing death twilight vampire chronicles vampires voodoo voodoo death voodoo doll zombie zombieism zombies Source Type: blogs
ConclusionsSupported by previous reports, our data suggest that it is both feasible and safe to perform translational experiments with parenteral albumin bound bilirubin.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: TRANSLATIONAL RESEARCH Source Type: research
Author Affiliations open 1Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK 2Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK 3Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland 4Swansea University Medical School, Swansea, Wales, UK 5University of Rochester Medical Center, Rochester, New York 6Department of Public Health, University of Copenhagen, Copenhagen, Denmark 7IUF Leibniz-Institut für Umweltmedizinische Forschung, Düsseldorf, Germany 8National Research Centre for the Working Environment...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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