Prediction of ventricular arrhythmias in patients with a spontaneous Brugada type 1 pattern: the key is in the electrocardiogram

AbstractAimsThere is currently no reliable tool to quantify the risks of ventricular fibrillation or sudden cardiac arrest (VF/SCA) in patients with spontaneous Brugada type 1 pattern (BrT1). Previous studies showed that electrocardiographic (ECG) markers of depolarization or repolarization disorders might indicate elevated risk. We aimed to design a VF/SCA risk prediction model based on ECG analyses for adult patients with spontaneous BrT1.Methods and resultsThis retrospective multicentre international study analysed ECG data from 115 patients (mean age 45.1  ± 12.8 years, 105 males) with spontaneous BrT1. Of these, 45 patients had experienced VF/SCA and 70 patients did not experience VF/SCA. Among 10 ECG markers, a univariate analysis showed significant associations between VF/SCA and maximum corrected Tpeak–Tend intervals ≥100 ms in precordial leads (LMaxTpec) (P 
Source: Europace - Category: Cardiology Source Type: research

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Conclusion of this paper: Fever is a great risk factor for arrhythmia events in Brugada Syndrome patients. Patients with known fever-triggered Brugada syndrome should be surveilled closely during fever and be started on antipyretic therapy as soon as possible.  There are limited data regarding the impact of EP study in BrS patients triggered by fever.  An EP study might be helpful in symptomatic patients (Sroubek et al., 2016) in the presence of spontaneous BrS ECG or drug-induced ECG.The prognostic significance of fever-induced Brugada syndrome.  Heart Rhythm 2016.Eighty-eight asymptomatic patient...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Publication date: Available online 2 December 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Anubha Kalra, Andrew LoweAbstractElectrocardiography (ECG) is widely used in clinical practice, for example to diagnose coronary artery disease or the cause of chest pain during a stress test, while the patient is running on a treadmill. However, artefacts due to subject’s movement are hard to identify and eliminate and can be easily mistaken for symptoms of arrhythmia, leading to misdiagnosis and false alarms. Skin stretch has been identified as a major source of motion artefacts in ECG signals.A Motion Artefact Rej...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
AbstractAconitine belongs to theAconitum alkaloids and is a natural toxic substance. Aconitine has been used as a traditional medicine in East Asian culture. Today, aconitine is still in use with or without a prescription, in the Republic of Korea. Here we present a case report of accidental death due to acute aconitine poisoning. An 81-year-old woman ingested liquid that had been heat extracted from the root of theAconitum plant; she presented to the emergency room 1  h after ingestion. Her electrocardiogram showed irregular ventricular arrhythmias including ventricular tachycardia; she progressed to cardiac arrest. ...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 Dec 03;171(11):828-836 Authors: Burns RB, Zimetbaum P, Lubitz SA, Smetana GW Abstract Atrial fibrillation (AFib) is the most common type of cardiac arrhythmia, affecting 2.7 million to 6.1 million persons in the United States. Although some persons with AFib have no symptoms, others do. For those without symptoms, AFib may be detected by 12-lead electrocardiogram (ECG), single-lead monitors (such as ambulatory blood pressure monitors and pulse oximeters), or consumer devices (such as wearable monitors and smartphones). Pulse pa...
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/ Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: The high variability of morphological findings and clinical manifestations of LVNC results in frequent overlooking of this disorder. Therefore, it is important to make the specialists more familiar with this condition and its pathology. Magnetic resonance imaging represents a conducive method to make correct diagnosis of LVNC under several specific conditions, particularly in case of non-conclusive echocardiographic finding. PMID: 31785212 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Conclusion: Live-firefighting induces significant ECG changes that include ventricular arrhythmias and ST segment changes, which may reflect myocardial ischemia. The implications of such ECG changes explaining increased cardiovascular risk in firefighters warrants further research.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: ORIGINAL ARTICLES Source Type: research
Authors: Zhang Q, Fu L, Gu L Abstract Motion artifacts and myoelectrical noise are common issues complicating the collection and processing of dynamic electrocardiogram (ECG) signals. Recent signal quality studies have utilized a binary classification metric in which ECG samples are determined to either be clean or noisy. However, the clinical use of dynamic ECGs requires specific noise level classification for varying applications. Conventional signal processing methods, including waveform discrimination, are limited in their ability to remove motion artifacts and myoelectrical noise from dynamic ECGs. As such, a ...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
A middle-aged woman was found down in her apartment unconscious. She was in shock with thready pulses.A prehospital ECG was recorded:Limb leads:Precordial LeadsWhat is the therapy?This is pathognomonic of hyperkalemia (I suppose it could be due to a massive overdose of a sodium channel blocking drug, maybe).Is it ventricular tachycardia (VT) due to hyperK or is it a supraventricular rhythm with hyperK? ---I don't think that it is possible to say for certain, and it does not matter.  The rate is not fast enough to be causing shock, so if it is VT, the priority is still to treat hyperK and secondarily to cardiovert...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
In this study, we sought to assess the prevalence of AF in patients with clinically undetected isolated cardiac amyloidosis (ICA) detected at autopsy and identify electrocardiographic (EKG) markers of such amyloid deposits. A total of 1083 patients were included in the study and 3.1% of patients were found to have asymptomatic ICA. Patients with ICA were older and had a higher odds of AF independent of age and CHA2DS2VASc score. Amongst patients with AF, those with ICA were more likely to have persistent forms of AF and had a lower sinus rhythm P-wave amplitude. Further studies are required to further define this entity, i...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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