Chronic Rhinosinusitis with Nasal Polyps in Older Adults: Clinical Presentation, Pathophysiology, and Comorbidity

AbstractPurpose of ReviewChronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients ’ life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical presentations, pathophysiology, and comorbidity associations including asthma.Recent FindingsRecent large population-based studies using nasal endoscopy have shown that CRSwNP is a mostly late-onset disease. Age-related changes in physiologic functions, including nasal epithelial barrier dysfunction, may underlie the incidence and different clinical presentations of CRSwNP in older adults. However, there is still a paucity of evidence on the effect of aging on phenotypes and endotypes of CRSwNP. Meanwhile, late-onset asthma is a major comorbid condition in patients with CRSwNP; they frequently present with type 2 inflammatory signatures that are refractory to conventional treatments when they are comorbid. However, as they are more commonly non-atopic, causative factors other than classical atopic sensitization, such asStaphylococcus aureusspecific IgE sensitization, are suggested to drive the type 2 inflammation. There are additional comorbidity associations in older patients with CRSwNP, including those with chronic otitis media and head and neck malignancy.SummaryAge is a major determinant for the incidence and clinical presentations of CRSwNP. Given the heterogeneity in phenotypes and endotypes, longitudinal investi...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research

Related Links:

No one I knew had food allergy, let alone peanut allergy, when I was a child. I grew up at a time when peanuts were given freely on airplanes, and there was no such thing as a peanut-free table at school. Fast forward to today and the world has changed, with food allergies taking on […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Allergies & Immunology Pediatrics Source Type: blogs
AbstractIn the modern world, healthy habits and physical and mental fitness are more important than ever. A growing number of people participate in sports to improve their overall health. However, the conditions in which people exercise are seldom examined. It is obvious that the air in buildings, including sports facilities, can be contaminated with pathogenic microorganisms, causing infections and allergies. Our study was aimed at assessing microbial air quality inside several sports facilities (fitness room, martial arts room, swimming pool, sports hall, gym) and at a sports field. Another objective was to evaluate the ...
Source: Aerobiologia - Category: Environmental Health Source Type: research
Granules India said it has received approval for Fexofenadine Hydrochloride tablets. The approved product is bio-equivalent to the reference listed drug product (RLD), Allegra Allergy Tablets, 60 mg and 180 mg, of Sanofi-Aventis US LLC.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
AbstractAsthma is a common chronic airways inflammatory disorder in which the expression of genes for the transcription factors FoxP3 and GATA3 plays crucial roles in activation of specific T cells population and pathogenesis of asthma. Recent data have shown that Hb, Eosinophils, total leucocytes count (TLC), absolute eosinophil count (AEC), and IgE, may be involved in adversely influencing the status of several chronic diseases including asthma. In this communication, we have carried out a case control study in order to evaluate the expression of FoxP3, GATA-3 genes in 80 bronchial asthmatic patients using real time poly...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
Conclusions: Anorectal function is impaired in IBD patients with perianal disease. Fecal incontinence correlates with poorer quality of life. Anorectal manometry and ultrasonography are useful tools for evaluating IBD patients. PMID: 31625422 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Last summer, the CBC's Jean Paetkau saved her seven-year-old son from an undiagnosed life-threatening allergy at a local pool. Paetkau describes how emergency training and a career in the newsroom helped her to cope with the crisis. The event changed her relationship with her son, ultimately creating a closer bond.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
New evidence shows that fatty tissue can build up in the airways, affecting lung health, especially in people with obesity. This may contribute to asthma.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
Refractory otitis media (OM) in adults is challenging as misdiagnosis can lead to permanent sensorineural hearing loss. OM in the presence of peripheral eosinophilia and atopic history should warrant alternative treatment rather than antibiotics and topical steroids.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M358 Source Type: research
Abstract The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. We conducted a cross-sectional study of 80 consecutively presenting patients-42 males and 38 females, aged 15 to 76 years (median: 48)-who were diagnosed with CRSwNP. Our aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients. The severity of CRSwNP was assessed on the basis of nasal symptoms, endoscopic nasal examinations, and Lund-Mackay staging scores. ...
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
Allergic rhinitis (AR) is a condition with a significant impact on patient's quality of life. Sex differences in the prevalence and clinical presentation of rhinitis have been reported in multiple studies. Additionally, it has comorbidities with asthma, atopic dermatitis, rhinosinusitis, otitis media, anosmia, nasal polyps and lower airway infection. As a complex phenotype, AR is affected by both genetic and environmental factors. Recent literature has focused on difference in the genomic architecture of asthma for the two sexes by considering gene-sex interaction, whereas AR has been neglected.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
More News: Allergy | Allergy & Immunology | Asthma | Cancer & Oncology | Endoscopy | Otitis | Otitis Media | Polyps | Study