Prevalence and Clinical Correlates of Self-Harm Behaviors in Gilles de la Tourette Syndrome

We examined 165 consecutive GTS patients aged 5–50 years old (75.8% males). The patients were evaluated for GTS and co-morbid mental disorders according to the DSM-IV-TR. SHB was diagnosed during the interview. To determine a direct relationship between SHB and clinical variables, we conducted two analyses, at the time of evaluation and lifetime. We also compared the group of children and adults with SHB and tried to distinguish between deliberate (non-tic related SHB) and accidental (tic related SHB). Lifetime SHB was reported by 65 patients (39.4%). In 30 of the patients (46.2%), SHB was evaluated as mild, in 26 (40%) as moderate and in only nine (13.9%) cases as severe. In the multivariable analysis for the predictor of lifetime SHB, attention deficit hyperactivity disorder (ADHD; p = 0.016) and obsessive-compulsive disorder (OCD; p = 0.042) were determined as risk factors, while for current SHB only tic severity (p
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

This study suggests that there is no difference in aggressive behavior between children with tics without comorbidities and healthy children. It is possible that aggressive behavior in children with tic disorders is predominantly associated with comorbid attention-deficit hyperactivity disorder.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
PURPOSE OF REVIEW The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals. RECENT FINDINGS Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing e...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Violent motor tics or severe self-harm behaviors have been reported in patients with Tourette's syndrome (TS) and leading to traumatic brain injury (TBI). The study aimed to determine the risk of TBI in TS patients, the effects associated with concurrent psychiatric disorders (attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or depressive disorder), and the effects of drug treatment (antipsychotics, antidepressants, or clonidine) on the risk of TBI.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Abstract While Behavioral Therapy (BT) should be recommended as the first step in the treatment of OCD as well as TS, medication can be added for augmentation and in certain situations (e.g. family preference, BT not available or feasible) the priority may even reverse. This narrative review is given on the complexity of drug treatment in patients comorbid for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) and other tic problems. OCD with TS is a co-occuring combination of two generally delimitable, but in detail also overlapping disorders which wax and wane with time but have different courses and...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
Tourette ’s syndrome (TS) is a childhood onset neurodevelopmental disorder characterized by the presence of motor and vocal tics. Tics fluctuate in frequency and intensity; they are sensitive to context and often amplified in exaggerated emotional states. Tics are often preceded by a stressful sensation, t he premonitory urge (Leckman et al. 1993). Comorbid disorders are common in TS and prominently include obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD) and affective disorders (Robertson 2006; Simpson et al.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Conclusion: The clinical course of TS during adolescence was confirmed, with solid evidence, with decline in tics, OCD and ADHD severity. We provide evidence of considerable coexisting psychopathologies requiring clinical support and partial remissions and subthreshold symptoms requiring monitoring and clinical guidance to assist the young adults in promoting a healthy transition into early adulthood. Furthermore we provide predictors for the clinical course of TS to be used in the preventive efforts, early intervention and allocation of resources improving quality of life for the children and their families. PMID: 296...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Abstract Background: Tourette syndrome (TS) is often co-morbid with attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Studies of TS, anxiety and depression have found variable results depending on study methodology and sample characteristics. Our aim was to examine the clinical utility of routine screening for anxiety and depression in children with TS. Methods: Using a clinic-based sample, we evaluated the proportion of children with TS meeting diagnostic criteria for ADHD, OCD, generalized anxiety disorder (GAD), separation anxiety disorder (SAD), and major depressive ...
Source: Journal of the Canadian Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: J Can Acad Child Adolesc Psychiatry Source Type: research
Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). It has been argued, however, that any observed association between TS and these and other psychopathologies may be due to ascertainment bias in that individuals with multiple problems are more likely to be referred for medical evaluation. A tic is a sudden, uncontrollable movement which can occur anywhere in the body or be vocal. Tics are often very mild and may not be noticeable to others but tics can also be grandiose.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Poster Source Type: research
Publication date: Available online 3 August 2017 Source:NeuroImage: Clinical Author(s): Liliana Polyanska, Hugo D. Critchley, Charlotte L. Rae Tourette Syndrome (TS) is a neurodevelopmental condition characterized by chronic multiple tics, which are experienced as compulsive and ‘unwilled’. Patients with TS can differ markedly in the frequency, severity, and bodily distribution of tics. Moreover, there are high comorbidity rates with attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), anxiety disorders, and depression. This complex clinical profile may account for apparent var...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
An international team led by researchers from UCLA and Massachusetts General Hospital has identified the first definitive genes associated with Tourette syndrome, giving scientists a long-sought foothold on the biology of the disease.The report in the June 21 issue of Neuron describes the discovery of rare mutations — either deletions or duplications of genetic material — in two neurodevelopmental genes, NRXN1 and CNTN6, in people with Tourette syndrome, a disorder characterized by multiple chronic, involuntary motor and vocal tics.“This is a first, key step in understanding the role of these genes in the...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
More News: ADHD | Children | Hyperactivity | Men | Obsessive Compulsive Disorder | Poland Health | Psychiatry | Study | Tics | Tourette Syndrome