Prevalence and Clinical Correlates of Self-Harm Behaviors in Gilles de la Tourette Syndrome

We examined 165 consecutive GTS patients aged 5–50 years old (75.8% males). The patients were evaluated for GTS and co-morbid mental disorders according to the DSM-IV-TR. SHB was diagnosed during the interview. To determine a direct relationship between SHB and clinical variables, we conducted two analyses, at the time of evaluation and lifetime. We also compared the group of children and adults with SHB and tried to distinguish between deliberate (non-tic related SHB) and accidental (tic related SHB). Lifetime SHB was reported by 65 patients (39.4%). In 30 of the patients (46.2%), SHB was evaluated as mild, in 26 (40%) as moderate and in only nine (13.9%) cases as severe. In the multivariable analysis for the predictor of lifetime SHB, attention deficit hyperactivity disorder (ADHD; p = 0.016) and obsessive-compulsive disorder (OCD; p = 0.042) were determined as risk factors, while for current SHB only tic severity (p
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Tourette syndrome (TS) and Chronic motor/vocal Tic Disorder (CTD) are neurodevelopmental conditions defined by the occurrence of multiple tics. Besides the well-known association with attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Tic disorders (TD) are a group neuropsychiatric disorders with childhood onset characterized by tics, i.e. repetitive, sudden, and involuntary movements or vocalizations; and Tourette syndrome (TS) is the most severe form of TD. Their clinical manifestations are diverse; and are often associated with various psychopathological and/or behavioral comorbidities, including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and sleep disorders. Individual severity and response to treatment are highly variable, and there are some refractory cases, which are less responsive ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Tourette syndrome (TS), also known as Tourette ’s disorder, is a neurodevelopmental disorder with onset in early childhood characterized by multiple motor tics and at least one vocal tic that have been present for longer than 1 year. TS is a model neuropsychiatric disorder, in that the vast majority of affected individuals, whether ascertained in clinical or community settings, experience at least one co-occurring psychiatric disorder, such as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and/or mood, anxiety, and specific learning disorders (1).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
IntroductionAlthough defined by the presence of tics, most patients with Gilles de la Tourette syndrome (TS) also suffer from different psychiatric disorders. While much is known about clinical characteristics of comorbidities such as attention deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), depression, and anxiety disorders, only very little is known about rage attacks. Most of this data is based on small studies in children. Until today no larger studies have been performed in adults with TS—most likely because of the lack of validated instruments. The aim of this study was to develop a ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study suggests that there is no difference in aggressive behavior between children with tics without comorbidities and healthy children. It is possible that aggressive behavior in children with tic disorders is predominantly associated with comorbid attention-deficit hyperactivity disorder.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
PURPOSE OF REVIEW The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals. RECENT FINDINGS Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing e...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Violent motor tics or severe self-harm behaviors have been reported in patients with Tourette's syndrome (TS) and leading to traumatic brain injury (TBI). The study aimed to determine the risk of TBI in TS patients, the effects associated with concurrent psychiatric disorders (attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or depressive disorder), and the effects of drug treatment (antipsychotics, antidepressants, or clonidine) on the risk of TBI.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Abstract While Behavioral Therapy (BT) should be recommended as the first step in the treatment of OCD as well as TS, medication can be added for augmentation and in certain situations (e.g. family preference, BT not available or feasible) the priority may even reverse. This narrative review is given on the complexity of drug treatment in patients comorbid for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) and other tic problems. OCD with TS is a co-occuring combination of two generally delimitable, but in detail also overlapping disorders which wax and wane with time but have different courses and...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
Tourette ’s syndrome (TS) is a childhood onset neurodevelopmental disorder characterized by the presence of motor and vocal tics. Tics fluctuate in frequency and intensity; they are sensitive to context and often amplified in exaggerated emotional states. Tics are often preceded by a stressful sensation, t he premonitory urge (Leckman et al. 1993). Comorbid disorders are common in TS and prominently include obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD) and affective disorders (Robertson 2006; Simpson et al.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Conclusion: The clinical course of TS during adolescence was confirmed, with solid evidence, with decline in tics, OCD and ADHD severity. We provide evidence of considerable coexisting psychopathologies requiring clinical support and partial remissions and subthreshold symptoms requiring monitoring and clinical guidance to assist the young adults in promoting a healthy transition into early adulthood. Furthermore we provide predictors for the clinical course of TS to be used in the preventive efforts, early intervention and allocation of resources improving quality of life for the children and their families. PMID: 296...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
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