Gastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy.

CONCLUSION: CART-related GI-AEs occur in 15% of patients treated with CART. These symptoms are typically mild and self-limiting, requiring only symptomatic treatment. Nevertheless, CART may, in rare cases, lead to refractory colitis. PMID: 31478934 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Am J Clin Oncol Source Type: research

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So in this "fellowship" that i resigned from recently, I asked long time ago whether tail was covered.I was told yes. When I signed paperwork after resigining I was told that I'd be covered for the premium for the tail. When I was like what?! That's not what I was told. I was told that "it would be covered if I finished the fellowship." That seems shady and illegal. Obviously paying thousands of dollars for tail would be reasonable on an attending salary, but now it seems they are pissed I... Tail coverage
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Victor Fattori, Tiago H. Zaninelli, Fernanda S. Rasquel-Oliveira, Rubia Casagrande, Waldiceu A. VerriAbstractWe now appreciate that the mechanism of resolution depends on an active and time-dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called specialized pro-resolving lipid mediators (SPMs). These SPMs are biosynthesized from the omega-3 fatty acids arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), or docosahexaenoic acid (DHA). Despite effective for a fractio...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Pelin Şenel, Soykan Agar, V. Oyku Sayin, Filiz Altay, Mine Yurtsever, Ayşegül GölcüAbstractFludarabine is a purine derivative, anti-neoplastic drug and is still being used in the treatments of chronic lymphocytic leukemia, small lymphocytic lymphoma, acute myeloid leukemia, Non-Hodgkin’s lymphoma. It achieves its function by interacting with DNA. Therefore, the binding interactions of such drugs with deoxyribonucleic acid (DNA) is an important subject for pharmaceutical and biochemic...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe authors recommended short implants whenever the height of available bone permits optimum implant placement. The authors concluded that both treatment options are considered viable clinically and radiographically. However, short implants have shown reduced postoperative discomfort, minimal invasiveness, and reduced cost.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionLimited available evidence suggests that patients with RAS may experience a reduction in the number of ulcers, DOU, NOE, and UP when using a SLS-free dentifrice as compared to using a dentifrice containing SLS.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin.In this experimental study, seventy male Wistar rats with an average weight of 270-320 g were randomly divided into 5 groups: control; sham, that received 25 μl of saline through the spinal catheter; and three experimental groups, that received 5, 10 or 20 mg/kg Melissa officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of Melissa officinalis on ...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
Publication date: Available online 17 November 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Sumit Kumar Hira, Kheyanath Mitra, Prateek Srivastava, Shikha Singh, Sambhav Vishwakarma, Ranjeet Singh, Biswajit Ray, Partha Pratim MannaAbstractA novel ABA-type polyethylene glycol (PEG)-b-polyketal (PK)-b-PEG block copolymer was synthesized via click reactions between the monoazido-monomethoxy-PEG and dialkyne terminated aliphatic polyketal with no carboxylic/amide linkages. Formation of the novel block copolymer was confirmed by 1H NMR, GPC, TGA and DSC studies. The formed copolymer has shown faster d...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Nehal Salahuddin, Mohamed Abdelwahab, Mohamed Gaber, Sahar ElneanaeyAbstractBiodegradable, biocompatible and non-toxic polymer-based nanoparticles are the novel nanotherapeutic tool which is used for adsorption and encapsulation drugs. Extended release formulation of Norfloxacin antibiotic, chemotherapeutic agent model, drug in the form of encapsulated and loaded poly (lactic acid) nanocomposites-based Titanium dioxide (PLA/TiO2) was developed. Nanocomposites were prepared using different contents (1, 3, 5 wt %) and morphologie...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
A 56-year-old automobile mechanic was referred to our rheumatology service by his orthopedist to evaluate left posterior knee pain and swelling that had been present for three months. The patient had undergone bilateral total knee arthroplasties (TKAs) for sports-related osteo­arthritis three years before. In addition to the knee pain, the patient described several years of... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Home Slider Rheumatoid Arthritis knee arthroplasty knee swelling popliteal cyst synovitis Source Type: research
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