Food, Acid Supplementation and Drug Absorption – a Complicated Gastric Mix: a Randomized Control Trial

ConclusionThe ability of food to elevate and maintain gastric pH levels in the presence of acid supplementation was made evident throughout the study. A 4500  mg dose of BHCl was required to reacidify gastric pH after the administration of food. This study details the difficulty faced by clinicians in dosing a poorly soluble, weakly basic drug to patients receiving acid reducing agents where administration with food is recommended to avoid gastric side effects.Trial Registration:https://clinicaltrials.gov/ct2/show/NCT02758015
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research