Incidence of sleep apnea and association with atrial fibrillation in an unselected pacemaker population: results from the observational RESPIRE study

Patients with atrial fibrillation (AF) often have sleep apnea (SA), but diagnosis of SA with polysomnography is costly. SA monitoring (SAM) is a pacemaker feature that measures respiratory disturbance index (RDI), the sum of abnormal respiratory events divided by sleep duration.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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Authors: Bashir MU, Bhagra A, Kapa S, McLeod CJ Abstract Atrial fibrillation is the most common symptomatic arrhythmia that is associated with stroke. Contemporary management of the disease is focused on anticoagulation to prevent stroke, coupled with catheter ablation to limit symptoms and prevent deleterious cardiac remodeling. Emerging data highlights the importance of lifestyle modification by managing sleep apnea, increasing physical activity, and weight loss. There is significant data that supports a link between the autonomic nervous system, arrhythmia development, and atrial fibrillation therapy. It is like...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
iRhythm and Verily announced a partnership last month to “co-develop solutions intended to provide early warning, diagnosis and management for patients, particularly for those with silent or undiagnosed AF.” We spoke with iRhythm CEO Kevi...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Diagnostics Exclusive irhythm verily Source Type: blogs
Purpose of review This review provides a contemporary review of sleep apnea with emphasis on definitions, epidemiology, and consequences. Recent findings Amyloid β-42 is one of the main peptides forming amyloid plaques in the brains of Alzheimer patients. Poorer sleep quality and shorter sleep duration have been associated with a higher amyloid burden. Decreased sleep time in the elderly is a precipitating factor in amyloid retention. Studies have shown that the dysregulation of the homeostatic balance of the major inhibitory and excitatory amino acid neurotransmitter systems of gamma-aminobutyric acid (GABA) and...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: SLEEP AND RESPIRATORY NEUROBIOLOGY: Edited by Lee Brown and Brian D. Kent Source Type: research
Conclusions: Obstructive sleep apnea diagnosis in atrial fibrillation patients was strongly associated with reduced risk of incident cardiovascular disease. We discuss misclassification, selection bias, and residual confounding as potential explanations.
Source: Epidemiology - Category: Epidemiology Tags: Sleep Source Type: research
Publication date: Available online 20 September 2019Source: Canadian Journal of CardiologyAuthor(s): P. Timothy Pollak, Marcus Povitz
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
CONCLUSIONS: The relationship between OSAS and ischaemic stroke is evident. The advance in the identification of molecular markers and low-cost studies for the identification of OSAS will allow implementing strategies to reduce their consequences in cardiovascular diseases, mainly in ischaemic stroke. PMID: 31497870 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
Central sleep apnea (CSA) is common in patients with atrial fibrillation (AF) with or without heart failure (HF). CSA is also a known trigger of new onset AF. Phrenic nerve stimulation (PNS) is an approved technology implanted by electrophysiologists shown to treat CSA effectively and safely.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 219 Source Type: research
AbstractPurpose of ReviewStroke prevention is the cornerstone of atrial fibrillation (AF) management and the anticoagulation decision is currently based on CHA2DS2-VASc risk score. We discuss several novel risk factors besides those included in CHA2DS2-VASc score and alternative models for stroke prediction.Recent FindingsSeveral clinical markers including obstructive sleep apnea and renal failure, laboratory markers like brain natriuretic peptide, imaging criteria including left atrial appendage morphology, spontaneous echo contrast, and coronary artery calcium score may predict stroke in AF patients. Addition of African ...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Abstract AIMS: Sleep apnea (SA) is a risk factor for atrial fibrillation (AF) occurrence. Sympathovagal imbalance is a mechanism that predisposes to the development of AF and that occurs in SA. Some pacemakers can detect SA events and continuously measure a time domain measure of heart rate variability (HRV), i.e. the standard deviation of 5-min median atrial-atrial sensed intervals (SDANN). We evaluated the association between the occurrence of AF and device-detected SA and SDANN in patients who received pacemakers. METHODS: We enrolled 150 consecutive patients undergoing implantation of a dual-chamber pacem...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
AbstractBackgroundWe evaluated the association of P wave duration (PWD) with LA scar in paroxysmal atrial fibrillation (PAF) patients.MethodsConsecutive PAF patients undergoing their first catheter ablation were screened and only those in sinus rhythm (SR) at baseline were included in the analysis. Standard 12 ‐leads ECG was performed in all and 3D voltage mapping of the left atrium was generated for identification of low‐voltage areas (≤0.2 mV) before the procedure.ResultsIn total, 411 paroxysmal AF patients were included in this study of which 181 had LA scars (scar group), while 230 had no scar (non ‐scar group...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
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