Harmonized Autophagy Versus Full-Fledged Hepatitis B Virus: Victorious or Defeated

Viral Immunology, Ahead of Print.
Source: Viral Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Publication date: Available online 6 December 2019Source: Microbial PathogenesisAuthor(s): Feng Zhu, Qiongfang Zhang, Qiongyue Zhang, Dazhi ZhangAbstractBackground and aimsRecent available treatment guidelines are pointing up clearance or seroconversion of hepatitis B e-antigen (HBeAg) as a valuable endpoint in treating HBeAg-positive chronic hepatitis B (CHB) patients. To evaluate the effect of combination therapy [interferon (IFN) plus nucleos(t)ide analogues (NAs)] versus IFN monotherapy on HBeAg seroconversion or seroclearance in HBeAg-positive CHB patients.MethodsAll available controlled clinical studies, published fr...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Condition:   Hepatitis B Virus (HBV) Interventions:   Biological: ETV/TDF+T101 No.1;   Biological: ETV/TDF+T101 No.2;   Biological: ETV or TDF;   Biological: ETV/TDF+Peg-IFNα-2b Sponsor:   Tasly Tianjin Biopharmaceutical Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion NLR is correlated with SUVmax-mean values in ICC and resulted to be an easy available predictor of survival in patients submitted to treatment with 90Y-microspheres.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Condition:   Hepatitis B Interventions:   Biological: Recombinant Hepatitis B (Bio Farma) Vaccine;   Biological: Recombinant Hepatitis B (Bio Farma) Vaccine® Sponsor:   PT Bio Farma Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review Subcutaneous implants are a promising technology to enable long-acting parenteral delivery of antiretroviral drugs (ARV) because they may be able to provide protective drugs concentrations for a year or longer following a single implant. The present review covers the current status of preclinical and clinical development of antiretroviral implants. Recent findings Over the past three decades, subcutaneous implants have been widely used for long-acting hormonal contraception and the treatment of hormonally-driven malignancies. They are economical and scalable to manufacture, but require special proced...
Source: Current Opinion in HIV and AIDS - Category: Infectious Diseases Tags: LONG ACTING ART FOR TREATMENT AND PREVENTION: Edited by Martin Markowitz Source Type: research
Authors: Guo D, Xu P, Guan C, Xu Y, Yang Y, Xu J, Zhou R, Chen B Abstract Hepatitis B virus (HBV) is a hepatotropic and a lymphotropic virus. An association between HBV and hematologic malignancies has been determined previously; however, the association between HBV infection and multiple myeloma (MM) remains controversial. The present study aimed to assess the prevalence of HBV infection in patients with MM, and investigate their characteristics and prognostic significance. The clinical data of 165 patients with MM who had received at least four cycles of chemotherapy between April 2008 and February 2017 at Nanjin...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Journal of Chemical Information and ModelingDOI: 10.1021/acs.jcim.9b01010
Source: Journal of Chemical Information and Modeling - Category: Chemistry Authors: Source Type: research
Publication date: Available online 4 December 2019Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Yu Zhu, Zhen-Yu Li, Chun-Guo Wang, Zhe-Ping Fang, Wei-Dong Jia, Fa-Biao Zhang
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Semin Liver Dis DOI: 10.1055/s-0039-3401031Chronic hepatitis B (CHB) virus infection is a global public health threat affecting approximately 257 million individuals worldwide. Hepatitis B surface antigen (HBsAg) loss has been the classic endpoint to define functional cure and decrease the large pool of individuals with CHB. Current treatments with nucleos(t)ide analogues persistently suppress hepatitis B virus (HBV) deoxyribonucleic acid in most CHB patients, but rarely achieve functional cure. New viral biomarkers, such as quantitative HBsAg, hepatitis B core-related antigen, and HBV ribonucleic acid, and combinations of...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
In this study, we describe a genome-wide CRISPR screen to identify other potential host factors required for HBsAg expression and to gain further insights into the mechanism of RG7834. We report more than 60 genes involved in regulating HBsAg and identify additional factors involved in RG7834 activity, including a zinc finger CCHC-type containing 14 (ZCCHC14) protein. We show that ZCCHC14, together with TENT4A/B, stabilizes HBsAg expression through HBV RNA tailing, providing a potential new therapeutic target to achieve functional cure in CHB patients.Graphical Abstract
Source: Cell Reports - Category: Cytology Source Type: research
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