Larval distribution, migratory pattern and histological effects of Toxocara canis in Rattus norvegicus

This study aimed to determine whetherT. canis could establish in Sprague –Dawley rats artificially infected with 500T. canis embryonated eggs and if the animals can be used as animal models for toxocariasis. Following squash method and tissue digestion, larvae were recovered from the lungs, liver and brain of the infected rats. Furthermore, gross examination of organs revealed macroscopic lesions and hemorrhages in the lungs and brain. Microscopically, accumulation of inflammatory cells, thickening of alveoli lining and destruction of bronchial walls and hepatic necrosis were observed. This study showed thatT. canis has established in Sprague –Dawley rats and could serve as a model forToxocara infection studies.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research