Targeting Mutant KRAS for Anticancer Therapy.

Targeting Mutant KRAS for Anticancer Therapy. Curr Top Med Chem. 2019 Sep 02;: Authors: Chen F, Alphonse MP, Liu Y, Liu Q Abstract Over the past decades, designing therapeutic strategies to target KRAS-mutant cancers, which is one of the most frequent mutant oncogenes among all cancer types, have proven unsuccessful regardless of many concerted attempts. There are key challenges for KRAS-mutant anticancer therapy, as the complex cellular processes involved in KRAS signaling has present. Herein we highlight the emerging therapeutic approaches for inhibiting KRAS signaling and blocking KRAS functions, in hope to serve as a more effective guideline for future development of therapeutics. PMID: 31475898 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research