029 The IL-31-producing circulating T cells subset represents a unique population of CLA+ CRTH2+ CCR4+ effector memory T cells

Recent findings underscore an important role of IL-31/IL-31RA signalling in pruritus. The novel TH2-derived cytokine interleukin-31 (IL-31) has been implicated in the pathophysiology of atopic dermatitis (AD) and induces pruritus via a synergistic cooperation of dysregulated immune cells and stimulated sensory neurons. In particular, the clinical efficacy of the IL-31RA-targeting antibody nemolizumab in treating itch in atopic dermatitis patients emphasized the importance of the IL-31/IL-31RA pathway.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: A. Datsi, K. Raba, S. Kellermann, A. van Lierop, P. Olah, R. Sorg, B. Homey Tags: Adaptive Immunity and Autoimmunity Source Type: research