043 Persistent deficiency of mucosal associated invariant T cells in dermatomyositis

Mucosal associated invariant T (MAIT) cells are innate like lymphocytes found in peripheral blood and mucosa; they are decreased during systemic lupus erythematosus and other auto-immune diseases. However, MAIT cell levels and functions have not previously been investigated in dermatomyositis (DM). Herein, we studied MAIT cells level and activation status before and after treatment during DM (n=21) and compared them to healthy controls (n=19), psoriasis (n=7) and atopic dermatitis (n=5). We showed that DM was associated with a dramatic reduced number of circulating MAIT cells (median: 0.12% [0.073-0.25%] versus 2.13% [1.05-3.94%], p

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: C. Cassius, M. Branchtein, M. Battistella, C. Lepelletier, A. De Masson, A. Bensussan, M. Bagot, H. Le Buanec, J. Bouaziz Tags: Adaptive Immunity and Autoimmunity Source Type: research