067 ULK1 alleviates psoriatic dermatitis by reversing the pathological changes of keratinocytes.

ULK1 is strongly linked to autophagy, proliferation, apoptosis and inflammation. Keratinocytes in psoriasis is characterized by excessive proliferation, reduced apoptosis, altered differentiation and increased cytokine secretion. The role of ULK1 in psoriasis has not yet been elucidated. Therefore, the aim of our work was to clarify the expression pattern of ULK1 in psoriatic lesions and its role in the pathogenesis of psoriasis. We found that the epidermal expression of ULK1 protein and its active form of p-ULK1 was significantly lower in psoriasis patients than in healthy controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research