094 Integration of multi-omic data identifies psoriasis endotypes correlating with clinical and immunological phenotypes

We are performing omic analyses of psoriasis and psoriatic arthritis (PsA) patients to address the hypothesis that biomarker discovery will inform more individualized care of individuals (endotypes) with psoriasis and their comorbidities. We collected whole blood from psoriasis patients (n=59, 16 PsA; mean PASI=8.6 (range 0-33.5) with 9 healthy controls) and PBMCs (n=9 psoriasis, n=5 controls). RNASeq was performed using Illumina TruSeq Total RNA kits and a NextSeq 550 (15M+ paired reads/sample, 75 bp).

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: M. Cameron, J. Golden, B. Richardson, G. Damiani, M. Ali, A. Young, C. Nichols, N. Ward, T. McCormick, K. Cooper Tags: Clinical Research and Epidemiology Source Type: research