110 Host-microbial dialogues in atopic dermatitis and psoriasis

Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we characterized skin microbial communities coupled to the global pattern of cutaneous gene expression. Patients with atopic dermatitis (AD, n=82) or psoriasis (PSO, n=119) lesions were recruited to the study and sampled for the skin microbiota and skin transcriptome. The skin microbiota was analysed by 16S rRNA gene and whole genome sequencing, and the skin transcriptome by DNA microarrays, followed by exploratory analysis and integration of the data layers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research