139 Immunological and clinical features of patients with persistent human herpesvirus 6 infection after drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms

Drug-induced hypersensitivity syndrome (DIHS) / drug reaction with eosinophilia and systemic symptoms (DRESS) is characterized by fever, cutaneous eruptions, hematological abnormalities, multiple organ dysfunction, and reactivation of human herpesviruses such as HHV-6 and CMV. Reactivation of HHV-6 and CMV has been reported to be involved in clinical course of DIHS. In addition, autoimmune diseases such as type 1 diabetes and thyroiditis sometimes develop after resolution of DIHS. We found that quite a few patients harbor high levels (> 1000 copies / 106 PBMC) of HHV-6 DNA in PBMC over 6 months after onset of DIHS.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research

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Conclusion: Patients with type 1 DM should be examined for thyroid diseases, and patients with suspected thyroid disease should be evaluated with a thyroid ultrasound. Type 1 DM and PTC coexistence albeit very rare; It should be known that type 1 diabetes can be seen together with thyroid cancer. PMID: 31686641 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research
Conclusion: This study is the largest to date analyzing the potential influence of neighborhood deprivation on ADs. Our results indicate that neighborhood deprivation may affect risk of ADs, independent of individual level sociodemographic characteristics. For health care policies, both individual and neighborhood level approaches seem to be of importance.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions: Our study showed a higher incidence of autoimmune diseases in TS, which is in line with the literature; however, the impact of iXq, or spontaneous / inducted puberty was not confirmed.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
We described a 9-month boy who was admitted to our hospital because of severe pneumonia and developed DRESS 3 weeks later. In addition, we performed a literature review of diabetes mellitus associated with DRESS by searching the PubMed. A total of 16 articles and 27 related case reports were obtained between 2001 and 2018. The mean age was 46yr. The duration from the onset of DRESS to the development of DM was 21d on average. 21 patients were diagnosed F1TD, 5 patients were confirmed T1DM, and 1 patient was defined T2DM. GAD were detected in 4 cases. Of 22 cases in which virus examination were carried out, evidence of viru...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Autoimmune thyroid diseases (AITDs), including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), tend to aggregate with other non-thyroidal autoimmune diseases (NTADs). Aim of this Mini-review is to report the most recent insights concerning the clustering of NTADs in pediatric patients with either HT or GD, the pathophysiology of AITDs and the metamorphic thyroid autoimmunity. A systematic literature research of the last fifteen years, according to EQUATOR statement, was carried out through MEDLINE via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) Embase, CINAHL, Cochrane Library, based on the following ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
If you or someone close to you have an autoimmune condition such as rheumatoid arthritis, lupus, Hashimoto’s thyroiditis, Crohn’s disease or ulcerative colitis, along with about 195 others, there are a number of steps you can take that reduce, even eliminate the autoimmune inflammation damaging your organs. (Unfortunately, some forms of autoimmune damage cannot be reversed. Autoimmune loss of pancreatic beta cells that lead to type 1 diabetes, Hashimoto’s thyroiditis that damages the thyroid gland, or autoimmune hepatitis that can lead to cirrhosis. for example, cannot be reversed even if the autoimmune p...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Autoimmunity autoimmune casein Gliadin grain-free omega-3 undoctored vitamin D wheat belly Source Type: blogs
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Background: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is characterized by fever, cutaneous eruptions, hematological abnormalities, organ disorder, and reactivation of human herpesvirus 6 (HHV-6). In addition, autoimmune diseases such as type 1 diabetes and thyroiditis may develop long-term after resolution of DIHS. Reactivation of HHV-6 has been reported to be involved in clinical condition of DIHS. We found that quite a few patients harbor high levels (> 1000 copies / 106 PBMC) of HHV-6 DNA in PBMC over 4 months after onset of DIHS.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
Publication date: Available online 11 January 2019Source: Autoimmunity ReviewsAuthor(s): Silvia Martina Ferrari, Poupak Fallahi, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Salvatore Benvenga, Alessandro AntonelliAbstractGraves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Here, we review...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion: HLA-DQB1 confers strong susceptibility by Ala57 homozygosity and protection by non-Ala57, both in adult isolated and polyglandular diseases. Frequencies of HLA-DQB1 amino acids differentiate between APS-2 T1D/AIT and AD/AIT. HLA-DQB1 Ala57 heterozygous women are at increased risk for AD or AIT, while males were found to have an increased susceptibility for T1D. PMID: 30590628 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
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