143 Oxidative stress as a cofactor in the relationship between lichen planus and hepatitis C virus infection

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease wherein cell mediated immunity plays a pivotal role. Regarding its pathogenesis, several hypotheses have been  suggested. Recent studies have focused on the role of oxidative stress. 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the major free radical resulted from the action of oxidative stress on nuclear and mitochondrial DNA. Considering the association of LP with hepatitis C virus (HCV) infection, the aim of our study is to evaluate 8-OHdG as an oxidative stress marker and observe the influence of HCV in LP patients.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: M.I. Mitran, C.I. Mitran, M. Tampa, I. Nicolae, M. Sarbu, C. Matei, S.R. Georgescu, M.I. Popa Tags: Clinical Research and Epidemiology Source Type: research