320 Skin microbiome in cutaneous T cell lymphoma by 16S and whole genome shotgun sequencing

In vitro studies have indicated that staphylococcal enterotoxin-producing bacteria promote activation of STAT3 in malignant cutaneous lymphoma (Sezary syndrome) T cells. We investigated the skin microbiome of patch stage mycosis fungoides (MF) compared to normal skin by 16S amplicon sequencing and whole genome shotgun sequencing (WGS). Swab specimens were taken from MF patches and contralateral healthy appearing skin of 20 patients. The most common genera were Staphylococcus (30,0 %), Corynebacterium (22,3 %) Propionibacterium (5,0 %) and Streptococcus (3,0 %).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research