334 Involvement of cathepsin S and protease-activated receptor-2 in ciguatoxin-induced substance P release: new promising targets to treat ciguatera pruritus

Ciguatera Fish Poisoning (CFP) is a widespread tropical intoxication consecutive to ciguatoxin (CTX) ingestion, which is characterized by persistent neuro-cutaneous disturbances, including an intense pruritus (itch). Currently, there is no specific treatment. The primary target of CTXs is the voltage dependent sodium channel (Nav), which is largely expressed in sensory nerves and, to a lesser extent, in keratinocytes. By activating Nav, CTXs induce neuronal hyper-excitability but the downstream molecular mechanisms leading to sensory disorders are poorly understood.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research