361 Nrf2 deficiency leads to keratinocyte susceptibility to apoptosis under oxidative stress in oral lichen planus

Keratinocytes in most chronic skin inflammatory lesions are undergoing continuing oxidative stress (OS) but with distinguishing outcomes, in which lesions of oral lichen planus (OLP) feature with extensive keratinocyte apoptosis in epidermis whereas keratinocyte hyper-proliferation is a histopathologic hallmark of psoriatic lesions. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the protogenic and induced expression of antioxidant and detoxification genes in order to regulate physiological and pathological outcomes of OS, but its involvement in OLP has not been investigated.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research