395 Mas-related G-protein coupled receptor-B2 participates in imiquimod induced dermatitis through degranulation of mast cell

Imiquimod (IMQ) is a common drug in skin disease treatment. However, the side effects of IMQ occurred frequently, which manifested as erythema, itch, and pain, while the mechanism has not been fully understood. Mast cells have been found at the lesion after IMQ treatment, and MRGPRX2 on mast cells has been proved to induce pseudo-allergic reaction in chronic urticaria, contact dermatitis, and other skin diseases. Whether IMQ related dermatitis is mediated by mast cell degranulation via MrgprB2/MRGPRX2 need to be addressed.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: Y. Hao, D. Che, B. Peng, Y. Zheng, L. He, S. Geng Tags: Innate Immunity and Inflammation Source Type: research