403 Increased Expression of Oncostatin M Receptor β in Chronic Pruritic Diseases

Chronic Pruritus (CP), a primary symptom in dermatological conditions, is often intractable and strongly impacts patient quality of life. Expression of CP-related biomarkers, Oncostatin M receptor β (OSMRβ) and Interleukin-31 (IL-31), were assessed in these CP-presenting diseases: Chronic Idiopathic Pruritus (CIP), Chronic Idiopathic Urticaria (CIU), Lichen Planus (LP), and Lichen Simplex Chronicus (LSC) and correlated with clinical features. mRNA and protein expression from archived skin s amples from disease and non-pruritic control patients were analyzed by RNAscope and Immunohistochemistry (IHC) methods for IL-31 and OSMRβ expression levels.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research