432 Transcriptome analysis reveals novel insights into the etiology and pathophysiology of Pityriasis Rubra Pilaris

PRP is an extremely rare inflammatory skin disorder characterized by scaly salmon-colored lesions that can cover the entire body. While the underlying cause of PRP is unknown, it displays overlapping clinical features with psoriasis, making diagnosis challenging. Some cases can spontaneously resolve but the clinical management of chronic cases is hindered by the lack of effective therapies. To shed light on the underlying molecular and cellular mechanisms of PRP, RNAseq was used to characterize dermal and epidermal transcriptomes of PRP and healthy skin.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research