433 An innervated, vascularized and immunocompetent human skin model to evaluate the properties of chemical substances

Pathogens, sensitizing chemicals and autoimmune diseases trigger T cell-driven inflammation in the skin under control of cutaneous Dendritic Cells (DCs). No in vitro human model recapitulates the features of cutaneous immune responses. Indeed, such models frequently lack an epidermal barrier, necessary to investigate topically applied compounds, and fail to acknowledge the influence of non-immune cells which modulate the activation of DCs and T cells. This represents a major shortcoming and prevents accurate pre-clinical evaluation of anti-inflammatory drugs, vaccine adjuvants or potentially allergenic chemicals (sensitizers).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research