549 Disappearance of keratinocyte expression of Glycoprotein Non-metastatic B (GPNMB) / Osteoactivin in vitiligo – possible involvement of Th1/Th 17 cytokines

GPNMB is a highly glycosylated type I transmembrane protein, which is known to be expressed in many cell types with multiple functions including cell adhesion, stress protection, and stem cell maintenance. In the skin, melanocyte GPNMB is suggested to mediate pigmentation through melanosome formation, but details of its expression and function in epidermal keratinocytes are not well characterized. We previously confirmed the predominant expression of GPNMB at a lower calcium condition in cultured normal human epidermal keratinocytes (NHEK).

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: K. Biswas, Y. Mizutani, S. Takayama, A. Ishitsuka, A. Iddamalgoda, A. Takahashi, L. Yang, F. Yang, I. Katayama, S. Inoue Tags: Photobiology and Pigmentation Source Type: research