461 Telomerase Reverse Transcriptase Mutations, Enzyme Activity and Telomere Length in Cutaneous Basal Cell Carcinoma

We aimed to:1) Analyse telomerase reverse transcriptase (TERT) mutations in cutaneous basal cell carcinoma (CBC) tumours and describe its relationship with intra-tumour enzyme activity and telomere length (TL). 2) Compare TERT activity between tumour and clinically healthy peritumoral skin. 3) Compare TL between CBC and peripheral blood. A cohort of 45 patients with 50 CBC were included. All tumours were located in the neck, face or scalp. Usual clinicopathological variables were recorded for each patient and tumour.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research