477 Generating Merkel cell polyomavirus reactive T cells from healthy donors for adoptive immunotherapy

Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine skin cancer that is highly immunogenic. Approximately 80% of MCC tumors are virus positive (VP-MCC) and express Merkel cell polyomavirus (MCPyV) T antigens that drive oncogenesis. As VP-MCC have a low mutation burden with few predicted neoantigens, viral oncogenes are thought to be the primary target for anti-cancer immunity. Immune checkpoint inhibitors improve MCC survival, yet

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: S.I. Davies, J. Barrett, P.J. Muranski, I. Brownell Tags: Melanoma and Other Skin Cancers Source Type: research