478 Expression of meiosis regulatory genes in cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is a non-Hodgkin lymphoma characterized by infiltrating malignant monoclonal T-lymphocytes. Differential diagnosis of CTCL poses a challenge to clinicians due to its propensity to mimic benign dermatoses such as psoriasis and eczema. Meiosis-specific cancer/testis (meiCT) antigens are a specialized group of genes expressed specifically in meiosis and epigenetically silenced in normal somatic cells, however recent research has demonstrated that a number of meiosis genes are ectopically upregulated in cancers, including CTCL.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: J.K. Gantchev, A. Mart ínez Villarreal, I.V. Litvinov Tags: Melanoma and Other Skin Cancers Source Type: research