483 Next-generation target sequencing analysis identifies multiple somatic mutations in basal cell carcinoma

Basal cell carcinoma (BCC) is the most common cutaneous neoplasia in fair-skinned individuals usually characterized by locally destructive growth and invasion of surrounding tissue. BCC is primarily driven by the aberrant activation of the Sonic Hedgehog pathway (HH), with the majority of BCCs carrying mutations in PTCH1 or SMO genes. However, the great variability in morphology, aggressiveness and response to treatment of BCC remains unexplained and highlights the hypothesis that additional genes might contribute to tumorigenesis of different BCC subtypes.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: L. Di Nardo, C. Pellegrini, M. Maturo, F. Ricci, A. Di Stefani, B. Fossati, T. Rocco, M. Fargnoli, K. Peris Tags: Melanoma and Other Skin Cancers Source Type: research