495 Liquid Biopsy in Merkel Cell Carcinoma: Detection of Circulating Tumor Cells and Identification of the Polyomavirus Status in Single Tumor Cells

The incidence of Merkel cell carcinoma (MCC), a rare and highly metastatic skin malignancy, has sharply increased in the last decade. Clinical biomarkers are urgently needed for MCC prognosis, treatment response monitoring, and early diagnosis of relapse. The clinical interest of circulating tumors cells (CTCs) has been validated in many solid cancers. The aim of this study was to compare CTC detection and characterization in blood samples of patients with MCC using the CellSearch ® System and the RosetteSep™ -DEPArray™ workflow, an innovative procedure to enrich, detect and isolate single CTCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research