496 STAT3 polymorphisms and IL-6 polymorphism are associated with the risk of basal cell carcinoma in patients from northern Poland

Basal cell carcinoma (BCC) environment consists of stromal and inflammatory cells which produce variety of cytokines, chemokines and growth factors that may affect the tumor behavior. One of the cytokines suggested to be involved in the pathogenesis of BCC is IL-6 - the upstream element of IL-6/JAK/STAT3 pathway. In the present study rs1800795 (-174 G/C) IL-6 gene polymorphism and STAT3 rs2293152 (intron 11, C/G) and rs4796793 ( –1697, C/G) polymorphisms were assessed in relation to the BCC risk and clinical course.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: M. Slawinska, M. Zablotna, J. Glen, J. Lakomy, R.J. Nowicki, M. Sobjanek Tags: Melanoma and Other Skin Cancers Source Type: research