505 Infantile Hemangioma angiogenesis and sensitivity to propranolol rely on a cross talk between vascular and perivascular stromal cells

Propranolol is currently the first-line treatment for severe infantile hemangioma (IH), the most frequent skin tumor in childhood. Neither the molecular mechanism of action of propranolol nor the cell type target of the drug has been identified with a strong proof of concept. We have developed an IH in vitro model using patient-derived endothelial cells, pericytes and PDGFR- α + stromal cells. The aim of this study is to investigate the role of these perivascular cells in IH vascular proliferation and in the antitumor effect of propranolol on IH angiogenesis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research