513 Dynamic change of PD-L1 expression in cutaneous angiosarcoma

Cutaneous angiosaroma(CAS) is a rare type of soft tissue sarcoma (STS) from endothelial origin. The prognosis is poor and 5-year survival rate is around 20 to 35%. Recent years, immune checkpoints including programmed cell death ligand 1 (PD-L1) and its receptor programmed cell death (PD-1) blockade therapy for various cancers are showing successful results. PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the cancer progression. Overexpression of PD-L1 in almost cancers such as malignant melanoma is associated with poor clinical prognosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research