586 New concept of cytokine balance in alopecia areata with atopic dermatitis

Alopecia areata (AA) is regarded as an organ-specific and cell-mediated autoimmune disorder. In cytokine balance of AA, several reports have suggested AA as Th1 disease. For example, Murine IFN- γ-injected C3H/HeJ mice showed AA like hair loss with infiltration of CD4+and CD8+T cells Th1 cytokine. In human, IFN-γ-producing cells were detected in the perifollicular infiltrate, and serum Th1 cytokines were increased in AA patients. On the other hand, AA often complicates atopic dermatitis ( AD). However, the immunological aspects of AA with AD are still poorly understood.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: R. Kageyama, T. Ito, S. Nakazawa, H. Hashizume, Y. Tokura Tags: Stem Cells, Skin Appendages and Tissue Regeneration Source Type: research