605 3D-SeboSkin model application in Hidradenitis suppurativa/acne inversa

Hidradenitis suppurativa/acne inversa (HS) is a chronic, recurrent skin disease of the hair follicle. It manifests with painful, deeply localized, inflammatory skin lesions that occur in apocrine gland-rich areas of the skin, most commonly in the axillae and the inguinal and anogenital regions (Dessauer definition). The central pathogenic event in HS is believed to be the occlusion of the hair follicle leading to a perifollicular lymphohistiocytic inflammation. The purpose of this work was to develop a human HS model which could help to understand the pathophysiology of HS and to determine the action of therapeutic candidates.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: X. Hou, A.M. Hossini, G. Nikolakis, C.C. Zouboulis Tags: Stem Cells, Skin Appendages and Tissue Regeneration Source Type: research