621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge

The regenerative nature of hair follicle (HF) stem cells (SCs) facilitates HF cycling and support skin regeneration. A reduction in HF SC number is a key factor in skin and HF aging and in the development of hair disorders, i.e. androgenetic alopecia and lichen planopilaris. Fruit SC-derived extracts reportedly have positive effects on the regenerative capacity of primary human epidermal SCs. Treatment with apple or grape SC extract increased the colony forming efficacy of primary human epidermal SCs, even under UV stimulation, and restored the organogenic potential of late passage primary human epidermal SCs to generate 3D epidermis in vitro.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Stem Cells, Skin Appendages and Tissue Regeneration Source Type: research