636 Mechano-sensing and inflammatory signalling in normal and keloid dermal fibroblasts

Keloid scar formation is associated with aberrant inflammatory signalling however the underlying causes remain poorly understood. Additionally, keloid scars have been shown to be 10-50 times stiffer than normal skin and often form in areas of the body where skin tension is high. As a result, it is thought that the formation of keloid scars may be influenced by mechanical forces. The aim of this study was to investigate the direct effects of tissue stiffness on the behaviour of normal (NF) and keloid fibroblasts (KF) and explore the potential cross-talk with inflammatory signalling pathways.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: R. Ross, J. Maxwell, X. Lui, J. Connelly Tags: Wound Healing and Tissue Remodelling Source Type: research