649 Hypoxia-pretreatment as a possible approach to stimulate wound healing potentials of dermal fibroblasts in treatment of chronic skin ulcers

The development of new therapeutic approaches to chronic wounds hasn ’t lost its relevance. In non-healing diabetic ulcers (diabetic foot) auto-transplantation (a common treatment approach) is not effective due to impaired fibroblast functionality and shifts in synthesis of ECM proteins (COL1, COL3, FN) and certain growth factors. It was shown that HIF1 (hypoxia-in duced factor) is a key regulator of ECM remodeling by fibroblasts through control of collagen prolyl hydroxylase (P4HA1, P4HA2 – both required for collagen deposition) and lysylhydroxylase (PLOD2 – modulates collagen fibers strength) expression.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: E.V. Solovieva, K.A. Darienko, A.A. Panteleyev Tags: Wound Healing and Tissue Remodelling Source Type: research