Effect of weight loss on neutrophil resolvins in the metabolic syndrome
There is increasing evidence for a positive association between low-grade inflammation and obesity and insulin resistance [1 –6]. The ongoing low-grade inflammation could in part be due to failed resolution to an inflammatory challenge. The inflammatory response requires recruitment of neutrophils as the first line of host defence to a pathogen and is controlled by prostaglandins and leukotrienes that derive from arachi donic acid (AA). Leukotriene B4 (LTB4) and chemokines cause neutrophil aggregation, adhesion, and degranulation.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: A. Barden, S. Shinde, I-J. Tsai, K.D. Croft, L.J. Beilin, I.B. Puddey, T.A. Mori Tags: Original research article Source Type: research
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