The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter [Biochemistry]
Legionella pneumophila causes a potentially fatal form of pneumonia by replicating within macrophages in the Legionella-containing vacuole (LCV). Bacterial survival and proliferation within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy. The vacuolar membrane-localized MavN, hypothesized to support iron transport, is unique among effectors because...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Eric T. Christenson, Dervla T. Isaac, Karin Yoshida, Erion Lipo, Jin-Sik Kim, Rodolfo Ghirlando, Ralph R. Isberg, Anirban Banerjee Tags: PNAS Plus Source Type: research