The Putative Association of TOB1 - AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

In this study, 39 MS patients and 32 healthy matched controls were recruited. Real-time PCR  standard curve method was used to quantify transcript levels ofTOB1-AS1, TOB1, SKP2, andTSG. In addition, the potential sex hormone receptor binding sites on target genes promoter were analyzed using JASPR software. This work demonstrates a negative correlation betweenTOB1-AS1 expression and EDSS of patients. Also, a robust dysregulation of co-expression ofTOB1-AS1 lncRNA and the coding genes in MS patients compared to controls was observed. Such dysregulation in this pathway may be related to MS pathogenesis and response to interferon treatment.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research

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Publication date: Available online 9 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Brenda Bertado-Cortés, Claudia Venzor-Mendoza, Daniel Rubio-Ordoñez, José Renán Pérez-Pérez, Lucy Andrea Novelo-Manzano, Lyda Viviana Villamil-Osorio, María de Jesús Jiménez-Ortega, María de la Luz Villalpando-Gueich, Nayeli Alejandra Sánchez-Rosales, Verónica García-Talavera
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: Paramagnetic rims might be a characteristic MRI finding for MS, and therefore they have potential as an imaging marker for differentially diagnosing MS from NMOSD using 3-T MRI. PMID: 33029961 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): T. Leist, S. Cook, G. Comi, X. Montalban, G. Giovannoni, A. Nolting, D. Damian, S. Syed, A. Galazka
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Carlos MARTIN SANCHEZ, Jose I CALVO ARENILLAS, Fausto J BARBERO IGLESIAS, Emilio FONSECA SANCHEZ, Jose M SANCHEZ SANTOS, Ana M MARTIN NOGUERAS
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Yuanyuan Wang, Xiaoyu Tian, Huacheng Zheng, Yinghui Guo, Yuexian Zuo, Mengdi Cong, Huifeng Zhang
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Neurología (English Edition)Author(s): V.M. Rivera, F. Gracia, A. Díaz
Source: Neurologia - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, Fernando Cendes
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Miceline Mésidor, Marie-Pierre Sylvestre, Ruth Ann Marrie, Marie-Claude Rousseau
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): H-P Hartung, T Berger, RA Bermel, B Brochet, WM Carroll, T Holmøy, R Karabudak, J Killestein, C Nos, F Patti, A Perrin Ross, L Vanopdenbosch, T Vollmer, R Buffels, M Garas, K Kadner, M Manfrini, Q Wang, MS Freedman
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: This large study did not support that a high intake of fibre and/or a low intake of meat had a high impact on the risk of late-onset CID. PMID: 33029091 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
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