The Putative Association of TOB1 - AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

In this study, 39 MS patients and 32 healthy matched controls were recruited. Real-time PCR  standard curve method was used to quantify transcript levels ofTOB1-AS1, TOB1, SKP2, andTSG. In addition, the potential sex hormone receptor binding sites on target genes promoter were analyzed using JASPR software. This work demonstrates a negative correlation betweenTOB1-AS1 expression and EDSS of patients. Also, a robust dysregulation of co-expression ofTOB1-AS1 lncRNA and the coding genes in MS patients compared to controls was observed. Such dysregulation in this pathway may be related to MS pathogenesis and response to interferon treatment.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research