Diversity in Genotype Distribution of Mycoplasma pneumoniae Obtained from Children and Adults.

Diversity in Genotype Distribution of Mycoplasma pneumoniae Obtained from Children and Adults. Jpn J Infect Dis. 2019 Aug 30;: Authors: Yan C, Yang H, Sun H, Zhao H, Feng Y, Xue G, Li S, Cui J, Ni S Abstract The aim of this study was to explore whether there was any special genotype responsible for the high prevalence of Mycoplasma pneumoniae (M.pneumoniae) infection in children. A total of 247 M. pneumoniae - DNA positive clinical specimens including 200 from children and 47 from adults collected in Beijing, China, during the same period were analyzed. We performed P1-restriction fragment length polymorphism analysis (RFLP), multi-locus variable number tandem repeat analysis (MLVA) and detected the macrolide resistance-associated mutations in 23S rRNA of the clinical specimens. In the present study, we observed P1 genotype 1 and MLVA type M4-5-7-2 accounted for the majority of the cases across all ages in Beijing. Macrolide resistance-associated mutations of M.pneumoniae was also at a high level with 90.5% (181/200) in children and 76.6% (36/47) in adults. However, more diverse genotypes and a higher prevalence of macrolide resistance-associated mutations were found in the pediatric specimens. Further investigations are warranted to help to explain the difference of morbidity and molecular characteristic in demographic spectrum. PMID: 31474699 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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