Evaluation of the roflumilast effect supplemented with linezolid in pleural empyema in rats caused by intrapleural S.aureus inoculation.

Evaluation of the roflumilast effect supplemented with linezolid in pleural empyema in rats caused by intrapleural S.aureus inoculation. Jpn J Infect Dis. 2019 Aug 30;: Authors: Kerget B, Araz Ö, Kerget F, Erol HS, Özmen S, Halıcı Z, Akgün M Abstract In addition to tube drains, pleural empyema is treated with antibiotics and anti-inflammatory drugs. We aimed to evaluate the anti-inflammatory activity of roflumilast combined with linezolid in a rat model of pleural empyema induced by Staphylococcus aureus.A total of 40 rats were separated into 7 groups: Sham (n=4), S. aureus inoculation (n=6), S. aureus + 10 mg/kg linezolid (n=6), S. aureus + 5 mg/kg roflumilast (n=6), S. aureus + 10 mg/kg linezolid+5 mg/kg roflumilast (n=6), S. aureus + 10 mg/kg roflumilast (n=6), and S. aureus + 10 mg/kg linezolid + 10 mg/kg roflumilast (n=6). Linezolid was administered 1 hour before and 12 hours after inoculation with S. aureus. Roflumilast was administered orally as a single dose 30 minutes before inoculation with S. aureus. Compared to linezolid alone, linezolid combined with 5 mg/kg roflumilast provided statistically significant improvement in TNF-alpha, IL-1 beta, vasodilation/congestion, and tissue/pleural PNM infiltration (p
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
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Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Kaul G, Saxena D, Dasgupta A, Chopra S Abstract Sarecycline hydrochloride (Seysara) is a novel, narrow-spectrum tetracycline derivative approved by the U.S. Food and Drug Administration (FDA) in October 2018 for the treatment of inflammatory non-nodular moderate to severe acne vulgaris. It was initially developed by Paratek Pharmaceuticals, Inc. (U.S.) and Allergan plc (U.S.), which later was acquired by Almirall S.A. (Barcelona, Spain). Almirall S.A. obtained U.S. FDA approval of oral sarecycline tablets under the trade name Seysara. Sarecycline exhibits antibacterial activity against important skin/soft ...
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